Quality Control of Herbal Drugs

About Book

ISBN 8190078844
Presentation Hardbound 816 Pages
Edition Reprint 2011
Weight 1.45 Kg
Author Dr Pulok K. Mukherjee
Price USD 150
Availability In Stock

The most exhaustive and comprehensive book ever available on the subject.

  • Safety and Toxicity in Herbal Drugs
  • Ethnobotany in Drug Evaluation
  • Macro-Morphographical Studies Development of Standardization Parameters
  • Phytoconstituents and Their Analysis
  • Extraction of Herbal Drugs
  • TLC - Detailed Procedures and Guidelines
  • HPTLC - Densitometry
  • Pharmacological Screening of Herbal Drugs
  • Good Agricultural and Harvesting Practices
  • Quality Assurance and Stability Testing of Herbal Drugs
  • Analytical Profiles of Selected Medicinal Plants Plus

Annexed Information Additional References Internet Resources for further information International Associations/Organizations

You Need This Book If You Are:

  • Grower of medicinal herbs
  • Wholesaler/Distributor
  • Manufacturer of Herb Extracts
  • Manufacturer of Herbal Formulations
  • Researcher
  • Academician
  • Regulatory Affairs Specialist

CONTENTS

Foreword

Preface

Part I – Introduction

ALTERNATIVE SYSTEMS OF MEDICINE

Historical Overview of Indian System of Medicine

Ayurveda – The Ancient Traditional Medicine

Siddha System of Medicine

Unani System of Medicine

Homeopathic Remedies

Tibetan System

Natural Products from Modern Medicine

Quality Control in Traditional Systems of Medicine

Limitations of Traditional Experience

Role of Traditional System of Medicine in Primary Health Care

World Situation on Traditional Medicine

Traditional Chinese Herbal Medicine and it’s Evaluation

Development of Traditional System of Medicine in India

Prospects of Traditional Medicine

References              

HERBAL REMEDIES – TOXICITY AND REGULATIONS

Importance of Herbal Therapies

Herbals versus Conventional Drugs

Efficacy of Herbal Medicinal Products

Validation of Herbal Therapies

Safety in Herbal Drugs

Toxicity in Herbals and Their Interactions

Adverse Reactions and Safety in Herbal Medicine

General Concepts of Evaluation and Quality Control

Pharmacodynamic and Pharmacokinetic Issues

Assessment by Drug Regulators

Herbal Drug Regulations in India

Basic and Applied Research

Bioassay-Guided Separation and Structural Characterization

References

ETHNOBOTANY AND ETHNOPHARMACOLOGY

Ethnobotany in Herbal Drug Evaluation

Impact of Ethnobotany in Traditional Medicine

The Extent of Plant Kingdom in Medicine

Ethnopharmacology in Drug Evaluation

New Developments in Herbals

Biological Diversity – Role in Herbal Drug Development

Drug Discovery from Natural Products

Issues in Medicinal Plant Research

References

 

Part II – Quality Control Techniques                                   

 

ADULTERATION AND DETERIORATION

Introduction

Types of Adulteration or Substitution of Herbal Drugs

Causes and Measures for Adulterations

Deterioration of Herbal Drugs

Control Measures for Deterioration

References                      

FACTORS AFFECTING HERB QUALITY

Introduction

Quality Standards of Herbal Products

Factors Relating To Quality of Herbal Drugs

Ecological Factors

Quality Assurance of Herbal Drugs                                          

SAMPLING PROCEDURES

Sampling Procedures

Determination of Foreign Matter                                    

MORPHOLOGICAL EXAMINATIONS

Organoleptic Evaluation

Macromorphological Evaluation

Cytomorphological Evaluation of Herbal Drugs                                  

MICROSCOPICAL EVALUATION

Introduction

Instruments for Microscopical Study

Evaluation of Crude Drugs by Microscopy

Microscopical Methods

Quantitative Analytical Microscopy                                

DEVELOPMENT OF STANDARDIZATION PARAMETERS

General Information

Determination of Solvent Extractive Values

Determination Ash Values

Determination of Total Solids

Determination of Crude Fibre

Determination of Moisture Content

Determination of Essential Oils in Crude Drugs

Microbial Infestation and its Determination

Determination of Bitterness Value

Determination of Hemolytic Activity

Determination of Swelling Index

Determination of Foaming Index

Determination of Tannins

Determination of Arsenic and Heavy Metals

Pesticides                                   

PHYTOCONSTITUENTS AND THEIR ANALYSIS

Introduction

Importance of Phytoconstituents in Therapy

Qualitative Analysis of Crude Drug Extracts and Isolates

Alkaloids and Their Analysis

Volatile Oils, Spices and their Analysis

Fixed Oils Fats and Waxes

Phenylpropanoids and their Analysis

Flavonoids

Resins and Resinous Plant Drugs and their Analysis

Tannins and their Analysis

Terpenoids and their Analysis

Glycosidal Components and their Analysis

Fluorescent Substances and their Analytical Parameters

Colouring Matters and their Analysis

Proteinaceous Components and their Analysis

Steroids

Carbohydrates and their Analysis                          

EXTRACTION OF HERBAL DRUGS

Introduction

Basic Principles and Rationale

Pre Extraction Operations for Crude Drugs

Effect of Solvent, Solvent Mixtures and Solution on Extraction

Characteristics of Phytoconstituents

Procedures for Extraction of Herbal Drugs

Interfering Compounds In Extraction of Desired Phytoconstituents

Extraction Methods for Specific Phytochemical Groups

Treatment of Drug Residue after Extraction

References              

THIN LAYER CHROMATOGRAPHY

Introduction

Basic Principles of TLC

Mechanisms for the Separation of Phytoconstituents

Adsorbents for Quantitative Thin-Layer Chromatography

Preparation of the Layers

Preparation and Application of Samples

Determination of Suitable Separation Conditions

Development of Chromatogram

Detection of Herbal Drugs and Extracts by TLC

Evaluation of the TLC Plates

TLC Bioautography

Quantitative Thin Layer Chromatography

Assay of Steroids in Phyto-Formulations

Assay of Alkaloids

Analytical Procedures for Some Bioactive Materials

References                              

HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY

HPTLC and Its Advantages

Requirements for HPTLC Standardization

Theory and Instrumentation of HPTLC

Theoretical Considerations for Quantitative Analysis

Specual techniques in In-situ Quantitative Evaluation

Quantitative HPTLC  for Pharmaceutical Applications

TLC-Densitometry in the Standardization of Medicinal Plant Extracts

References

                  

Part III – Biological Screening                           

 

PHARMACOLOGICAL SCREENING OF HERBAL DRUGS

Introduction

Need For Phyto-Pharmacological Evaluation

Hippocratic Screening for Evaluation of Natural Products

New Strategies for Evaluating Natural Products

Evaluation of Antidiabetic Agents

Evaluation of Hepatoprotective Agents

Evaluation of Liver Carcinogenesis

Evaluation of Diuretic Agents

Evaluation of Antidiarrhoeal Agents

Evaluation of Uterine Tonic Agents

Evaluation of Anti Ulcers Agents

Evaluation of Hypolipidemics Agents

Evaluation of Wound Healing Agents

Evaluation of Anti-Tussive Agents

Evaluation of Cardiovascular Agents

Evaluation of Anti-inflammatory Agents

Evaluation of Analgesic/Antinociceptive Agents

Evaluation of Antipyretic Agents

Evaluation of Repellant and Anti-feedant

Evaluation of Antioxidant Agents

Evaluation of Enzyme Activators and Inhibitor Agents

Evaluation of Myorelaxant and Antispasmodic Agents

Evaluation of CNS Agents

Evaluation of Natural Products Active on Brain

Evaluation of Antifertility Agents

Evaluation of Tyrosinase Inhibitory Agents

References                               

ANTIMICROBIAL AND PARASITICIDAL SCREENING OF HERBAL DRUGS

Introduction

Preparation of Plant Samples for Antimicrobial Screening

General Methods for Antimicrobial Screening

Some Phyto-constituents with Antimicrobial Activity

Antibacterial Screening Method

Assay For Phytopharmaceuticals Having Antifungal Activity

Screening For Anti-micobacterial Activity

Molluscicidal and Piscicidal Activity Evaluation

Evaluation of Antigiardial Effect

Assay For Antimalarial Activity

Assays For Amoebicidal Activity

References                                   

SCREENING FOR ANTIVIRAL ACTIVITY  

Introduction

Phytoconstituents with Antiviral Potentials

General Concepts of Evaluation

Factors Influencing Evaluation

Requirements for Host Cells, Organisms and Culture Media

General Screening Procedures for Antiviral Testing

Evaluation of Cytotoxicity

Antiviral Screening Models

Evaluation of Anti-influenza Activity

Preparation of Different Reagents for Antiviral Study

References

                       

Part IV – Legal Aspects                                 

 

GOOD AGRICULTURAL AND HARVESTING PRACTICES

Introduction

Good Harvesting Practices

Good Agricultural Practices

Documentation Required                             

QUALITY ASSURANCE AND STABILITY TESTING OF HERBAL DRUGS

Indicative Substances for Quality Assurance

Gmp and Haccp in Traditional Systems of Medicine

Physical Quality Assurance

Quality Assurance by Cultivation and Breeding

Stabilization and Stability

Methods of Stabilization

Validation of Analytical Procedures

References                                 

ANALYTICAL PROFILES OF SELECTED MEDICINAL PLANTS

Introduction

General Guidelines

Preparation of Spray Reagents

Analytical Profiles

              Acorus calamus             

              Adhatoda vasica

              Aegle marmelos

              Andrographis paniculata

              Bacopa monnieri

              Berberis aristata

              Boswellia serrata

              Cassia tora

              Centella asiatica

              Coleus forskohlii

              Commiphora mukul

              Curcuma longa

              Emblica officinalis

              Gardenia gummifera

              Gloriosa superba

              Glycyrrhiza glabra

              Mallotus philippinensis

              Mangifera indica

              Peganum harmala

              Phyllanthus amarus

              Piper longum

              Piper nigrum

              Psoralea corylifolia

              Withania somnifera

              Zingiber officinale

Annexure – 1 Websites on Herbal Medicines

Annexure – 2 International Herbal Organizations and Associations

Annexure – 3 References on Quality Control of Natural Products

Index

Acknowledgements


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