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The
combination of pharmaceuticals and light usually results in degradation
processes, and sometimes it may be used for targeted delivery of drug molecules.
Stabilization of photo-labile drug substances within formulations is a critical
aspect to control directly impacting the quality of the product. This is an
authoritative reference on the methods for screening photo-reactivity,
Photostability testing of drugs and problems associated with the formulation of
photo-labile substances. Technical requirements and equipment for photochemical
stability and testing have been outlined in the book as well as inconsistencies
and deficiencies which exist in the current official regulations concerning the
photolytic degradation of drugs. The subject is covered from a unique
pharmaceutical formulation viewpoint, which will be extremely useful to
pharmaceutical manufacturers and developers worldwide.
About
the Author – Hanne Hjorth Tønnesen is Professor in Pharmaceutics at
the University of Oslo, Norway and has particular research interests in
photochemical stability and photoreactivity testing of pharmaceuticals.
Contents
Photostability
of Drugs and Drug Formulations, 2nd Edition
Ch. 1 Introduction : Photostability testing of drugs and drug formulations - why
and how?
Ch. 2 Photophysical and photochemical aspects of drug stability
Ch. 3 Standardization of kinetic studies of photodegradation reactions
Ch. 4 Rationalizing the photochemistry of drugs
Ch. 5 Technical requirements and equipment for photostability testing
Ch. 6 Photostability testing : design and interpretation of tests on new drug
substances and dosage forms
Ch. 7 The questions most frequently asked
Ch. 8 Inconsistencies and deficiencies in current official regulations
concerning photolytic degradation of drugs
Ch. 9 Biological effects of combinations of drugs and light
Ch. 10 In vitro screening of the photoreactivity of antimalarials : a test case
Ch. 11 Screening dyes, drugs, and dietary supplements for ocular phototoxicity
Ch. 12 Photochemical and photophysical methods used in study of drug
photoreactivity
Ch. 13 Addressing the problem of light instability during formulation
development
Ch. 14 Photostability of parenteral products
Ch. 15 Photoactivated drugs and drug formulations
Ch. 16 Formulation approaches for improving solubility and its impact on drug
photostability
App. 1 Useful terms and expressions in the photoreactivity testing of drugs
App. 2 Relevant literature on the photostability of specific drug substances and
drug formulations
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